Development of micro-CT protocols for in vivo follow-up of mouse bone architecture without major radiation side effects

► In theory, micro-CT imaging can monitor changes in bone structure in living mice ► Actually, radiation exposure has to be weighed against image quality ► We developed and validated a protocol for in vivo micro-CT imaging of mouse bones ► This protocol retains high quality images but avoids radiation-induced side effects ► This micro-CT protocol enables to track the effect of disease or therapy on bone