Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts

► Strontium ranelate induces in human osteoarthritic subchondral bone osteoblasts a decreased resorptive activity. ► Strontium ranelate modulates in human osteoarthritic subchondral bone osteoblasts the synthesis of key factors leading to bone resorption. ► Strontium ranelate could limit the extent of human osteoarthritic subchondral bone matrix degradation through the inhibition of MMPs.