Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes

► A hydrostatic compression system was used to examine Ihh signal transduction under the influence of mechanical load. ► Hydrostatic compression increased both Ihh gene expression and Ihh-responsive Gli-luciferase activity. ► These increases were aborted by disrupting the primary cilia structure with chloral hydrate.