کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5891972 | 1153283 | 2012 | 8 صفحه PDF | دانلود رایگان |

Scanning probe microscopy (SPM) has been in use for 30Â years, and the form of SPM known as atomic force microscopy (AFM) has been around for 25 of those years. AFM has been used to produce high resolution images of a variety of samples ranging from DNA to carbon nanotubes. Type I collagen and many collagen-based tissues (including dentin, tendon, cartilage, skin, fascia, vocal cords, and cornea) have been studied with AFM, but comparatively few studies of bone have been undertaken. The purpose of this review is to introduce the general principles of AFM operation, demonstrate what AFM has been used for in bone research, and discuss the new directions that this technique can take the study of bone at the nanoscale.
⺠Brief history of atomic force microscopy and basic AFM operation (imaging and indentation). ⺠Summary of AFM's strengths and weaknesses. ⺠Investigating bone cell activity and canilicular structure. ⺠Studies of bone mineral and collagen. ⺠Mechanical characterizations in bone.
Journal: Bone - Volume 50, Issue 1, January 2012, Pages 420-427