Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody

► Denosumab markedly reduced cortical and trabecular bone remodeling in OVX cynos. ► Denosumab reduced trabecular eroded surfaces and cortical porosity. ► Lowest levels of remodeling at each site were associated with greatest structural strength. ► Cortical remodeling parameters had little or no relationship with cortical material properties. ► Denosumab effects on remodeling were fully reversible upon clearance of drug.