In situ accumulation of advanced glycation endproducts (AGEs) in bone matrix and its correlation with osteoclastic bone resorption

► Autofluorescence intensity of decalcified bone is associated with AGEs concentration. ► Variation of AGEs accumulation depends on both biological and chronological aging. ► Highest AGEs concentration is present around cement lines. ► In situ concentration of AGEs promotes osteoclastic bone resorption activities.