ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans

► ATF936, a novel calcilytic, functions as an efficacious PTH- secretagogue. ► It triggers transient elevations of endogenous PTH in rats and in dogs, and is moderately bone anabolic in rats. ► In humans, transient releases of PTH show an exposure profile close to that observed after s.c. teriparatide. ► Translational data constitute a proof-of-concept for this chemical class of calcilytics.