کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5892181 1153301 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of 20% demineralization on surface physical properties of compact bone scaffold and bone remodeling response at interface after orthotopic implantation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Effects of 20% demineralization on surface physical properties of compact bone scaffold and bone remodeling response at interface after orthotopic implantation
چکیده انگلیسی

To enhance osteointegration with preservation of mechanical strength, a surface modification technique using 20% surface demineralization in a controlled manner was applied to custom-built cylindrical bio-derived compact bones (20% surface-demineralized cylindrical compact bio-derived bone scaffold: SDCBS); an undemineralized version was the control. The micro-surface topography of the two types of bone scaffolds was characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). 20% demineralization led to significant increases in surface roughness (38.19%, P = 0.001) and surface area (15.1%, P = 0.030), compared with the control group's, while the decrease in mechanical properties was not statistically significant. Results of orthotopic implantation for 9 months demonstrated that 20% surface demineralization caused significantly rapid and homogeneous bone remodeling at the interface compared to control and led to a significantly rapid osteointegration of SDCBS with the host bone at the early and intermediate stages of osteointegration. The study indicates the potential of SDCBS in repairing clinical bone defects, and would help direct the use of various processes of biomaterials to support defect repairs within osseous sites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 45, Issue 2, August 2009, Pages 301-308
نویسندگان
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