کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5892302 1153317 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relating osteon diameter to strain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Relating osteon diameter to strain
چکیده انگلیسی

Osteon diameter is generally smaller in bone regions that experience larger strains. A mechanism relating osteon diameter to strain is as yet unknown. We propose that strain-induced osteocyte signals inhibit osteoclastic bone resorption. This mechanism was previously shown to produce load-aligned osteons in computer simulations. Now we find that it also predicts smaller osteon diameter for higher loads. Additionally, we find that our model predicts osteon development with two cutting cones, one moving up and one moving down the loading axis. Such 'double-ended osteons' were reported in literature as a common type of osteon development. Further, we find that a steep gradient in strain magnitude can result in an osteonal tunnel with continuous resorption along the less strained side, which corresponds to 'drifting osteons' reported in literature.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 43, Issue 3, September 2008, Pages 476-482
نویسندگان
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