کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5893987 | 1568423 | 2011 | 6 صفحه PDF | دانلود رایگان |
Central nervous system development is a complex process involving many interacting factors. MicroRNAs have recently been identified as playing key intrinsic roles in development however few of their specific targets have been identified in vivo. The transcription factor Sox9 has recently been identified as a target of miR-124 in the adult mouse sub-ventricular zone. Here we investigate the expression of the microRNAs miR-124, miR-128 and miR-23 and that of transcription factor Sox9, in neuroepithelial stem cells in the developing spinal cord. Furthermore we investigate if neurogenesis in embryonic neuroepithelial cells in the spinal cord might also be regulated by the interaction of Sox9 and miR-124. We provide evidence of the spatial and temporal regulation of miR-124, miR-128, miR-23 and Sox9, and taken together with recent findings we provide evidence that Sox9 may also be target of miR-124 in developing spinal cord neuroepithelial cells.
Research highlightsⶠmiR-124 and miR-23 are both expressed in spinal cord tissue prior to the appearance of astrocytes and neurons, in which they are thought to play a role. ⶠIn situ hybridization revealed that miR-124 and Sox9 have a complementary expression pattern in the developing spinal cord. ⶠWe provide evidence that transcription factor Sox9 is a target of miR-124 in the developing spinal cord neuroepithelium cells.
Journal: International Journal of Developmental Neuroscience - Volume 29, Issue 1, February 2011, Pages 31-36