کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5896477 1154957 2015 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Classical nuclear hormone receptor activity as a mediator of complex biological responses: A look at health and disease
ترجمه فارسی عنوان
فعالیت گیرنده هورمون کلاسیک هسته ای به عنوان واسطه واکنش های بیولوژیکی پیچیده: نگاهی به سلامت و بیماری
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Nuclear hormone receptors are a large family of receptors that bind a wide range of lipolic hormones and intracellular ligands. They act as ligand-inducible transcription factors to regulate the expression of target genes and play important roles in normal development, reproduction, and metabolism. NRs bind to hormones steroids, thyroid hormone, and vitamin D as well as metabolites of fatty acids, cholesterol, and bild acids. Orphan receptors are another group of NRs for which no known ligands have been identified yet but appear to have major roles in regulating intracellular metabolism. Targeting NRs has been a major source for the development of new drugs, particularly selective agonists and antagonists for cancer and metabolic diseases. Additionally, hormone resistance syndromes in man have enlarged our understanding of the functions of specific NRs and their isoforms as well as genetic mechanisms for phenotype expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 29, Issue 4, August 2015, Pages 517-528
نویسندگان
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