کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5898450 | 1155303 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TNF-α system and lung function impairment in obesity
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کلمات کلیدی
PaCO2CT90OSASPaO2FEV1aHIFVCTLCFEF25–75 - FEF25-75inflammation - التهاب( توروم) Pulmonary disease - بیماری ریویCOPD - بیماری مزمن انسدادی ریهChronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهResidual volume - حجم باقی ماندهobstructive sleep apnea syndrome - سندرم آپنه انسدادی خوابapnea-hypopnea index - شاخص آپنه-هیپوپنیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیforced vital capacity - ظرفیت حیاتی اجباریTotal lung capacity - ظرفیت کل ریهtumor necrosis factor - فاکتور نکروز تومورarterial oxygen pressure - فشار اکسیژن شریانیarterial carbon dioxide pressure - فشار دی اکسید کربن شریانیforced expiratory volume in 1 second - مجاز خروج مجدد در 1 ثانیهObesity - مرض چاقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
A potential interaction between pulmonary function, abnormal adipose tissue activity, and systemic inflammation has been suggested. This study explores the relationship between circulating soluble TNF-α receptors (sTNF-R1 and sTNF-R2) and respiratory function parameters in obese subjects. Thirty-one non-diabetic morbidly obese women with a history of non-smoking and without prior cardiovascular or respiratory disease were prospectively recruited in the outpatient Obesity Unit of a referral center. Pulmonary function test included a forced spirometry, static pulmonary volume measurements, non-attended respiratory polygraphy, and arterial gas blood sampling. Circulating levels of sTNFR-R1, sTNF-R2, interleukine 6 and adiponectin were determined using ELISA. Statistical analysis included a multivariate regression analysis taking into account the potential confounders. sTNF-R1 positively correlated with BMI (r = 0.571, p = 0.001) and arterial carbon dioxide pressure (PaCO2, r = 0.381, p = 0.038), but negatively with forced expiratory volume in 1 s (FEV1, r = â0.437, p = 0.012), maximum midexpiratory flow (FEF25-75, r = â0.370, p = 0.040) and forced vital capacity (FVC, r = â0.483, p = 0.005). However, no correlation between sTNF-R2 and BMI and either pulmonary function tests or arterial blood samples was observed. Multiple linear regression analysis showed that sTNF-R1 independently predicted FEV1 (beta = â0.437, p = 0.012) and FVC (beta = â0.483, p = 0.005). Thus, circulating levels of sTNF-R1, but not sTNF-R2, are related to reduced lung volumes and airflow limitation in morbidly obese patients prior to the development of a clinically recognized respiratory disease. Therefore, studies addressed to evaluating the potential beneficial effect of anti-TNF-α agents on pulmonary function tests in obese subjects seem warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 54, Issue 2, May 2011, Pages 121-124
Journal: Cytokine - Volume 54, Issue 2, May 2011, Pages 121-124
نویسندگان
A. Lecube, G. Sampol, X. Muñoz, R. Ferrer, C. Hernández, R. Simó,