Effects of sitagliptin on the serum creatinine in Japanese type 2 diabetes

- We conducted a study of Japanese type 2 diabetes patients taking sitagliptin.
- We found a slight elevation of Cr in the subjects treated with sitagliptin.
- The new finding is a correlation between elevation of Cr and reduction of HbA1c.
- Cr elevation is associated with activation of incretin, with up-regulation of GLP-1.

We found a slight elevation of serum creatinine in the subjects treated with sitagliptin for 2 years and a correlation between creatinine elevation and HbA1c reduction. These results suggest that creatinine elevation is associated with activation of incretin, most possibly with up-regulation of diuretic activity of GLP-1.