کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5900603 1568823 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo visualization of aromatase in animals and humans
ترجمه فارسی عنوان
تجسم حیوانی آروماتاز ​​در حیوانات و انسانها
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


- Aromatase can be visualized in vivo using PET and [11C]vorozole.
- Aromatase concentrations are slightly higher in males than in females.
- Highest brain concentrations are found in rat and monkey amygdala and human thalamus.
- Liver has high non specific uptake of radioactivity in all species following [11C]vorozole administration.
- Aromatase PET may improve diagnosis and treatment in brain disorders and cancer.

Aromatase catalyzes the last and obligatory step in the biosynthesis of estrogens across species. In vivo visualization of aromatase can be performed using positron emission tomography (PET) with radiolabeled aromatase inhibitors such as [11C]vorozole. PET studies in rats, monkeys and healthy human subjects demonstrate widespread but heterogeneous aromatase availability in brain and body, which appears to be regulated in a species, sex and region-specific manner. Thus, aromatase availability is high in brain amygdala and in ovaries of all species examined to date, with males demonstrating higher levels than females in all comparable organs. However, the highest concentrations of aromatase in the human brain are found in specific nuclei of the thalamus while the highest levels in rats and monkeys are found in the amygdala. Regional brain aromatase availability is increased by androgens and inhibited by nicotine. Future studies may improve diagnosis and treatment in brain disorders and cancers overexpressing aromatase.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Frontiers in Neuroendocrinology - Volume 40, January 2016, Pages 42-51
نویسندگان
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