کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5900668 1155972 2014 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex differences in stress-related psychiatric disorders: Neurobiological perspectives
ترجمه فارسی عنوان
اختلالات جنسی در اختلالات روانپزشکی مرتبط با استرس: دیدگاه های نوروبیولوژی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Stress is associated with the onset and severity of several psychiatric disorders that occur more frequently in women than men, including posttraumatic stress disorder (PTSD) and depression. Patients with these disorders present with dysregulation of several stress response systems, including the neuroendocrine response to stress, corticolimbic responses to negatively valenced stimuli, and hyperarousal. Thus, sex differences within their underlying circuitry may explain sex biases in disease prevalence. This review describes clinical studies that identify sex differences within the activity of these circuits, as well as preclinical studies that demonstrate cellular and molecular sex differences in stress responses systems. These studies reveal sex differences from the molecular to the systems level that increase endocrine, emotional, and arousal responses to stress in females. Exploring these sex differences is critical because this research can reveal the neurobiological underpinnings of vulnerability to stress-related psychiatric disorders and guide the development of novel pharmacotherapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Frontiers in Neuroendocrinology - Volume 35, Issue 3, August 2014, Pages 303-319
نویسندگان
, ,