کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5901379 | 1568917 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The embryonic pineal gland of the chicken as a model for experimental jet lag
ترجمه فارسی عنوان
غده هیپوفیز جنین مرغ به عنوان یک مدل برای عقب ماندگی جت آزمایش
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کلمات کلیدی
ساعت، عنات، هیومت، ریتم شبانه روزی، غده پینه آل، تأخیر فاز جنین، مرغ،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
The circadian clock in the chicken pineal model develops before hatching, at around the 17th embryonic day (ED17). By this stage, it runs in synchrony with environmental cues. To address if phase resetting mechanisms are comparable to those of post-hatched chicken, we investigated ED19 stage chicken embryos under 12Â h light:12Â h dark (LD), under constant darkness (DD), or under acute 4Â h phase delay of the LD condition (LDÂ +Â 4). The 24Â h mRNA-expression patterns of clock gene clock and of clock controlled genes Aanat and hiomt were analyzed with qRT-PCR. Under DD the rhythm of Aanat did not change significantly, however the 24Â h pattern of hiomt was altered. Clock shows a delayed response to DD with a phase-shift in its rhythm. After the first cycle under LDÂ +Â 4 conditions, the 24Â h patterns of Aa-nat and hiomt mRNA-s were phase delayed. Clock showed both acute and delayed changes in response to LDÂ +Â 4. These results show that the embryonic chicken pineal gland has a fully functioning clock mechanism, and that it is a good model for phase-change experiments. In addition it demonstrates that only one cycle of altered light schedule is sufficient to trigger changes within the molecular clock mechanisms of the chicken embryonic pineal model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 188, 1 July 2013, Pages 226-231
Journal: General and Comparative Endocrinology - Volume 188, 1 July 2013, Pages 226-231
نویسندگان
Siri Kommedal, Valér Csernus, András D. Nagy,