کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5902252 1156846 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fracture risk in patients with newly diagnosed type 2 diabetes: a retrospective database analysis in primary care
ترجمه فارسی عنوان
خطر شکستگی در بیماران مبتلا به دیابت نوع 2 تازه تشخیص داده شده: یک تجزیه و تحلیل پایگاه داده گذشته نگر در مراقبت های اولیه
کلمات کلیدی
دیابت نوع 2، خطر شکستگی، مراقبت های اولیه، پوکی استخوان، آنالیز بیماری،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

AimsIt is unclear whether fracture risk is increased in newly diagnosed type 2 diabetes patients. In addition, fracture risk of various sites (hip, spine, upper extremity) was analysed.MethodsThe study included 299,104 primary care patients from 1,072 practices who received a first type 2 diabetes diagnosis during the index period (01/2000-12/2013) (Disease Analyser, Germany). Furthermore, 299,104 non-diabetic controls were included after individual matching (1:1) to diabetes cases on age, sex, type of health insurance (private or statutory) and index date (visit at date of first diabetes diagnosis). Cumulative incidence of fractures was estimated for 10 years after index date using product-limit methods. Hazard ratios were calculated using Cox regression models adjusting for comorbidity.ResultsCumulative 10-year incidence of any, hip, spine, wrist/hand, forearm, and upper arm/shoulder fractures were 15.4%, 2.9%, 2.6%, 5.1%, 2.3%, and 2.3% in diabetes patients and 13.1%, 2.0%, 2.1%, 4.6%, 2.2%, and 1.7% in controls (log-rank test: all p < 0.001, except wrist/hand p = 0.56, forearm: p = 0.54), respectively. In multivariate Cox regression models, newly diagnosed type 2 diabetes was related to an significantly increased risk of any fracture (adjusted hazard ratio, HR, 95% CI: 1.36, 1.32-1.40), as well as for hip (1.56, 1.45-1.67), spine (1.37, 1.28-1.47), wrist/hand (1.15, 1.03-1.27), forearm (1.12, 1.05-1.20), and upper arm/shoulder (1.61, 1.49-1.74) fractures.ConclusionsAlready few years after diabetes diagnosis, type 2 diabetes patients more frequently experienced overall, hip, spine, and upper extremity fractures, respectively. The underlying mechanisms need to be further explored in order to prevent fractures among patients with type 2 diabetes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 29, Issue 6, August 2015, Pages 766-770
نویسندگان
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