کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5903494 1157082 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia
چکیده انگلیسی
The MRL mouse strain is the first naturally occurring mouse strain that we are aware of that is resistant to HFD-induced metabolic changes. Furthermore, the increased pAMPK suggests a proximal mechanism for these beneficial metabolic differences. We further hypothesize that these metabolic differences and plasticity provide the basis for the MRL mouse strain's super healing characteristics. This project's ultimate aim is to identify novel therapeutic targets, which specifically increase pAMPK.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 63, Issue 12, December 2014, Pages 1577-1586
نویسندگان
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