کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905885 | 1159942 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association analysis of bovine Foxa2 gene single sequence variant and haplotype combinations with growth traits in Chinese cattle
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کلمات کلیدی
Haplotype combinationForkhead box A2HNF-3SNPsPICHWEDlk1SVSFOXA2Association - اتحادیهSequence variants - انواع توالیExpectation Maximization - به حداکثر رساندن انتظاراتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceHardy–Weinberg equilibrium - تعادل هاردی-وینبرگfat mass and obesity associated - توده چربی و چاقی مرتبط استFTO - دعوتdelta-like 1 - دلتا 1PCR–RFLP - روش PCR-RFLPGrowth traits - صفات رشدHepatocyte nuclear factor 3 - عامل هسته ای هپاتوسیت 3Linkage disequilibrium - عدم تعادل پیوستگیpolymorphism information content - محتوای اطلاعات پلی مورفیسمUTR یا untranslated regions - منطقه ترجمه نشدهSequence variant - نوع توالیSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیpolymerase chain reaction–restriction fragment length polymorphism - پلیمورفیسم طول قطعه واکنش زنجیره پلیمرازCattle - گاو
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Forkhead box A2 (Foxa2) has been recognized as one of the most potent transcriptional activators that is implicated in the control of feeding behavior and energy homeostasis. However, similar researches about the effects of genetic variations of Foxa2 gene on growth traits are lacking. Therefore, this study detected Foxa2 gene polymorphisms by DNA pool sequencing, PCR-RFLP and PCR-ACRS methods in 822 individuals from three Chinese cattle breeds. The results showed that four sequence variants (SVs) were screened, including two mutations (SV1, g. 7005 C>T and SV2, g. 7044 C>G) in intron 4, one mutation (SV3, g. 8449 A>G) in exon 5 and one mutation (SV4, g. 8537 T>C) in the 3â²UTR. Notably, association analysis of the single mutations with growth traits in total individuals (at 24Â months) revealed that significant statistical difference was found in four SVs, and SV4 locus was highly significantly associated with growth traits throughout all three breeds (PÂ <Â 0.05 or PÂ <Â 0.01). Meanwhile, haplotype combination CCCCAGTC also indicated remarkably associated to better chest girth and body weight in Jiaxian Red cattle (PÂ <Â 0.05). We herein described a comprehensive study on the variability of bovine Foxa2 gene that was predictive of molecular markers in cattle breeding for the first time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 536, Issue 2, 25 February 2014, Pages 385-392
Journal: Gene - Volume 536, Issue 2, 25 February 2014, Pages 385-392
نویسندگان
Mei Liu, Mijie Li, Shaoqiang Wang, Yao Xu, Xianyong Lan, Zhuanjian Li, Chuzhao Lei, Dongying Yang, Yutang Jia, Hong Chen,