کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905910 | 1159943 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations of MYH3 gene copy number variations with transcriptional expression and growth traits in Chinese cattle
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کلمات کلیدی
CGHMYH3Myosin heavy chain 1Qinchuan cattleCNVsBTF3PP1PP2GAPDHSNPsqPCRAssociation - اتحادیهstandard deviation - انحراف معیارcomparative genomic hybridization - ترکیب هیبریداسیون ژنومی مقایسه شدهGrowth traits - صفات رشدquantitative real-time PCR - واکنش زنجیره ای پلیمراز واقعی در زمان واقعیSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیCopy number variations - کپی تغییرات شمارهCattle - گاوglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Associations of MYH3 gene copy number variations with transcriptional expression and growth traits in Chinese cattle Associations of MYH3 gene copy number variations with transcriptional expression and growth traits in Chinese cattle](/preview/png/5905910.png)
چکیده انگلیسی
Copy number variations (CNVs) have been recently recognized as another important genetic variability complementary to single nucleotide polymorphisms (SNPs). Compelling evidence has indicated that CNVs are responsible for phenotypic traits by changing the copy numbers of functional genes. Myosin heavy chain 3 (MYH3) gene is a critical regulatory factor in skeletal muscle development, and has been detected in the CNVs region by comparative genomic hybridization (CGH) array. This study was conducted to validate and detect the distribution of MYH3 copy numbers (relative to Angus cattle) in four Chinese cattle breeds (NY, QC, LX, and CY), and further to investigate the associations of the copy number changes with its transcriptional expression and cattle growth traits. Substantial genetic differences of MYH3 copy numbers were identified between NY and the other three breeds (PÂ <Â 0.01). The copy numbers of MYH3 gene presented the positive correlations with the transcript level of MYH3 gene in both fetal and adult skeletal muscles (PÂ <Â 0.05). Statistical analysis revealed that CNVs of MYH3 gene were significantly associated with growth traits of NY cattle, and the individuals with copy number gain showed better phenotypes than the loss and/or median groups (PÂ <Â 0.05). This study firstly attempted to establish the correlations between CNVs of candidate genes and growth traits, and our results suggested that the CNVs of MYH3 gene may be utilized as the potential markers for economic traits in selection breeding programs of Chinese cattle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 535, Issue 2, 10 February 2014, Pages 106-111
Journal: Gene - Volume 535, Issue 2, 10 February 2014, Pages 106-111
نویسندگان
Yao Xu, Tao Shi, Hanfang Cai, Yang Zhou, Xianyong Lan, Chunlei Zhang, Chuzhao Lei, Xinglei Qi, Hong Chen,