کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5906515 | 1159973 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1790 G/A polymorphism, but not 1772 C/T polymorphism, is significantly associated with Cancers: An update study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 1790 G/A polymorphism, but not 1772 C/T polymorphism, is significantly associated with Cancers: An update study 1790 G/A polymorphism, but not 1772 C/T polymorphism, is significantly associated with Cancers: An update study](/preview/png/5906515.png)
چکیده انگلیسی
This study aimed to investigate the association between PASD8 gene and cancers. For 1772 C/T polymorphism (rs11549465), it included 5552 cases and 8044 controls, and for 1790 G/A (rs11549467), 3381 cases and 5830 controls. The allele-analysis results showed that 1772 C/T (rs11549465) was significantly associated with cancers (OR: 1.177, 95% CI: 1.011-1.369, p = 0.035). And results of genotype-analysis indicated that 1790 G/A (rs11549467) had a significant relationship with cancers. (OR: 0.736, 95% CI: 0.595-0.910, p = 0.005). For 1790 G/A (rs11549467), the association was significant when subdivided by different kinds of cancers. And no association existed when subdivided into population-type subgroups. In conclusion, PASD8 gene played an important role in the development of cancers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 523, Issue 1, 1 July 2013, Pages 58-63
Journal: Gene - Volume 523, Issue 1, 1 July 2013, Pages 58-63
نویسندگان
Jie Liu, Hong-xin Zhang,