Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes

► We studied the association between SSNHL and CFH Y402H polymorphism. ► We conducted a case-control study. ► The cases were 72 SSNHL patients and the controls were 2161 residents. ► CFH Y402H polymorphism and SSNHL risk are significantly related. ► Diabetic CFH Y402H minor allele carriers may be susceptible to SSNHL.