کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5908599 1570167 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phylogenetic analysis of Indian rabies virus isolates targeting the complete glycoprotein gene
ترجمه فارسی عنوان
تجزیه و تحلیل فیلوژنتیک جدایه های ویروس هاری هندی با هدف گیری ژن کامل گلیکوپروتئین
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
چکیده انگلیسی
Rabies a fatal viral zoonosis is endemic in India. There is no report on phylogenetic study of Indian rabies virus isolates based on the complete G gene. In the present study, a total of 25 rabies positive brain samples collected during 2001-2014 from North India (UP, MP, Delhi, Rajasthan), South India (Kerala and Karnataka) and Gujarat states belonging to six different host species were subjected to G gene amplification by RT-PCR as three overlapping fragments of 881 bp, 991 bp and 618 bp. Phylogenetic analysis revealed that all Indian rabies virus isolates are genetically closely related with Arctic-like 1a lineage viruses. However, two distinct clusters were identified namely, India South and India North. All the Indian rabies isolates had 95.5-100% homology related to geography, but not to host species. Deduced amino acids on comparison revealed two amino acid changes, aa 356 in ECTO; N → K and aa 458; M → I, which were found to distinguish between the India South and India North isolates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 36, December 2015, Pages 333-338
نویسندگان
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