Short communicationInterplay of autophagy and apoptosis during PRRSV infection of Marc145 cell

- We discovered that both autophagy and apoptosis were induced by PRRSV infection.
- We uncovered that the replication of PRRSV is attenuated by autophagy deficient.
- We revealed that PRRSV replication is potentiated by apoptosis inhibition.
- We unveiled that PRRSV replication is restored by apoptosis inhibition in autophagy deficient cells.

Autophagy and apoptosis play essential roles 'in virus infection. Our study was performed to investigate the interplay between autophagy and apoptosis in PRRSV replication. In our present study, autophagy and apoptosis were induced by PRRSV infection. Viral replication was dampened/attenuated by autophagy deficient and potentiated by apoptosis inhibition. Furthermore, PRRSV replication was restored by apoptosis inhibition in autophagy deficient cells. Taken together, our findings unveil the functional relationship between autophagy and apoptosis during PRRSV replication.