Diversity of VP7 genes of G1 rotaviruses isolated in Iran, 2009-2013

- This study evaluated the genetic diversity of G1 RVs isolated in Iran, 2009-2013.
- Sequences obtained from GenBank were used to make genetic and phylogenetic analyses.
- RV strains from Iran clustered with G1 lineages IA, IC and IIC.

Genotype G1 of rotaviruses (RVs) is the most prevalent strain in human RV infections around the world. The present study evaluated genetic variations in the VP7 gene of RV G1 genotype isolates from Iran. Genetic and phylogenetic analyses indicated that RV strains from Iran clustered with G1 lineages IA, IC, and IIC, showing highest average of similarity versus reference sequences of the G1 lineages I and II. This study highlights the genetic pattern of G1 RV on the basis of distinct lineages and sublineages and indicates the importance of continuous monitoring on genetic variation and evolution pattern of G1 RV strains across the Iranian population for the final aim of RV vaccine introduction.