کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5909276 1570178 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevalence of the Sickle Cell Trait in Gabon: A nationwide study
ترجمه فارسی عنوان
شیوع ویروس سلول ساکشن در گابون: مطالعه در سراسر کشور
کلمات کلیدی
بیماری سل سقط، پیگمی بانت گابن، محیط زیست، سیر تکاملی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
چکیده انگلیسی


- There are marked differences in HbS prevalence across Gabonese provinces.
- There is a significant increase in HbS prevalence with age.
- Pygmy people have a significantly lower HbS prevalence than Bantu people.

Sickle Cell Disease (SCD) is an important cause of death in young children in Africa, which the World Health Organization has declared a public health priority. Although SCD has been studied at the continental scale and at the local scale, a picture of its distribution at the scale of an African country has never been given. The aim of this study is to provide such a picture for the Republic of Gabon, a country where precisely the epidemiology of SCD has been poorly investigated. To this effect, 4250 blood samples from persons older than 15 were collected between June 2005 and September 2008 in 210 randomly selected villages from the nine administrative provinces of Gabon. Two methods were used to screen Sickle Cell Trait (SCT) carriers: isoelectric focusing (IEF) and high-performance liquid chromatography (HPLC). SCT prevalence in Gabon was 21.1% (895/4249). SCT prevalence was significantly larger for the Bantu population (21.7%, n = 860/3959) than for the Pygmy population (12.1%, n = 35/290), (p = 0.00013). In addition, the presence of Plasmodium sp. was assessed via thick blood examination. Age was positively associated with SCT prevalence (odds-ratio for an increase of 10 years in age = 1.063, p = 0.020). Sex was not associated with SCT prevalence. The study reveals the absence of homozygous sickle-cell patients, and marked differences in SCT prevalence between the Gabonese provinces, and also between population groups (Bantu vs Pygmy). These findings could be used by the public health authorities to allocate medical resources and target prevention campaigns.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 25, July 2014, Pages 52-56
نویسندگان
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