کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5910427 1161353 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Old and new selective pressures on Mycobacterium tuberculosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Old and new selective pressures on Mycobacterium tuberculosis
چکیده انگلیسی
Tuberculosis (TB) has been affecting humans for millennia. There is increasing indication that human-adapted Mycobacterium tuberculosis complex (MTBC) has been co-evolving with different human populations. Some of the most important drivers of MTBC evolution have been the host immune response and human demography. These old selective forces have shaped many of the features of human TB we see today. Two new selective pressures have emerged only a few decades ago, namely HIV co-infection and the use of anti-TB drugs. Here we discuss how the emergence of HIV/TB and drug resistance could impact the long-term balance between MTBC and its human host, and how these changes might influence the future evolutionary trajectory of MTBC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 12, Issue 4, June 2012, Pages 678-685
نویسندگان
, ,