کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5910629 1570187 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Full genome analysis and characterization of influenza C virus identified in Eastern India
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Full genome analysis and characterization of influenza C virus identified in Eastern India
چکیده انگلیسی

In tropical countries of Asia, like India, approximately 0.5 million children of <5 years of age die annually due to acute respiratory illness (ARI). Of common respiratory pathogens, influenza viruses (A & B) are associated with annual worldwide epidemics; while the information on influenza C virus is inadequate. During January 2011 through December 2012, 2737 nasal and/or throat swabs were collected from patients reporting at outpatient department of hospitals in eastern India with ARI. Nucleotide sequencing was carried out using gene specific primers followed by pair-wise sequence alignments, multiple alignments, construction of phylogenetic tree and analysis of deduced amino acid sequences. Study reveals that, out of 2737 samples, 1616 (59.04%) were positive for one or more respiratory viruses; of which 23.72% were positive for influenza A and B viruses. From influenza A & B negative samples, influenza C virus was screened and detected with a frequency of 0.18%. Phylogenetic analysis showed that the HE, matrix, NS, PB1 and PB2 gene of the studied strain (C/Eastern-India/1202/2011) possessed a close relatedness to C/Yamagata/26/81 like strains. The P3 gene shows proximity with C/Mississipi/80 like strains whereas NP gene revealed similarity with C/Miyagi/1/93 like strains. The outcome of the whole genome analysis of the strain C/Eastern-India/1202/2011 provided useful information regarding genetic diversity of influenza C strains in India.

► Information of endemic strains from Indian subcontinent was largely unknown due to lack of any systemic study. ► This is the first report regarding whole genome analysis of influenza C virus from eastern India. ► Influenza C virus causes URTI, hence regular surveillance is required. ► Genetic lineage identification would offer additional data for epidemiological purpose.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 16, June 2013, Pages 419-425
نویسندگان
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