کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5910924 | 1570189 | 2013 | 7 صفحه PDF | دانلود رایگان |

Cooperation or interaction of programmed cell death-1 (PD-1) and T cell immunoglobulin and mucin domain-containing molecule-3 (Tim-3) molecules is more relevant than either molecule alone to immune dysfunction in chronic viral infection and cancers. This study simultaneously investigated polymorphisms at PD1 +8669 and TIM3 â1516 loci in 845 hepatitis B virus (HBV) chronically infected patients [151 asymptomatic carriers, 202 chronic hepatitis, 221 cirrhosis and 271 hepatocellular carcinoma (HCC)], 141 HBV infection resolvers and 318 healthy controls. Multivariate analysis showed that, in addition to gender, age, ALT, albumin and HBV DNA, PD1 +8669 genotype AA was associated with cirrhosis compared with patients without cirrhosis (OR, 2.410; PÂ =Â 0.001). TIM3 â1516 genotypes GTÂ +Â TT, together with gender, age, ALT, AST, direct bilirubin, albumin and HBeAg status, were associated with HCC compared with cirrhosis patients without HCC (OR, 2.142; PÂ =Â 0.011). The combined carriage of PD1 +8669 AA/TIM3 â1516 GT or TT was higher in cirrhosis and HCC pooled patients than in patients without cirrhosis (OR, 2.326; PÂ =Â 0.020) and in HCC patients than in cirrhosis patients (OR, 2.232; PÂ =Â 0.013). These data suggest that PD1 and TIM3 polymorphisms may differentially and interactively predispose cirrhosis and HCC in chronic HBV infection.
- Polymorphisms at PD1 +8669 and TIM3 â1516 loci were simultaneously investigated in HBV patients.
- PD1 +8669 AA and TIM3 â1516 GTÂ +Â TT were associated with cirrhosis and HCC, respectively.
- The carriage of PD1 +8669 AA/TIM3 â1516 GT or TT was associated with cirrhosis and HCC.
- PD1 and TIM3 polymorphisms may differentially and interactively predispose HBV-related cirrhosis and HCC.
Journal: Infection, Genetics and Evolution - Volume 14, March 2013, Pages 240-246