The origin of two rare human P[10] rotavirus strains

► Whole genomic analysis of a human G4P[10] rotavirus strain, 57M. ► The exact origin of human G8P4[10] rotavirus strain 69M remains to be elucidated. ► 57M has 69M-like VP4, NSP3 and NSP5 genes on a human Wa-like genetic backbone. ► 69M Originated from reassortment involving artiodactyl and human DS-1-like strains. ► The present study revealed the complex evolutionary patterns of P[10] rotaviruses.