Rotavirus in diarrheal children in rural Burkina Faso: High prevalence of genotype G6P[6]

► Few studies have characterized rotavirus in rural areas of Africa. ► Our results showed high prevalence of unusual G6P[6] genotype in rural areas of Burkina Faso. ► Sequencing of VP4 and VP7 genes demonstrated high diversity within the P-genotypes. ► Detection of a rare G8P[6] genotype for the first time in Burkina Faso. ► The emergence and high prevalence unusual RV strains could have implications for vaccine efficacy.