Genetic polymorphism of interleukin-16 influences susceptibility to HBV-related hepatocellular carcinoma in a Chinese population

► Polymorphisms of the IL16 gene were studied. ► Rs11556218T/G TG and GG genotypes will increase the risk of HBV-related HCC. ► Subjects with G allele appeared to have higher susceptibility to HBV-related HCC. ► Rs4072111C/T TT genotype will increase the risk of HBV-related HCC. ► IL-16 gene polymorphisms may be a useful genetic marker for HBV-related HCC.