کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
591428 1453669 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determining the Size Dependence of Colloidal Gold Nanoparticle Uptake in a Tumor-like Interface (Hypoxic)
ترجمه فارسی عنوان
تعیین میزان وابستگی جذب نانوذرات طلا کلوئیدی در رابطهای مشابه با تومور (کمپلکس)
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی

Colloidal gold nanoparticles (GNPs) are being used as drug delivery vehicles and radiation dose enhancers in cancer therapy. Oxygen concentration in human tumours is highly heterogeneous with many regions at very low levels of oxygen (hypoxia). A majority of tumours contain regions with oxygen pressure values of less than 0.7% in the gas phase. The purpose of this study was to investigate how the size of the NPs affects their uptake process in a tumour-like hypoxic environment. We used GNPs of diameter 15, 50, and 74 nm, and carried out our experiment under 0.2% (hypoxic) and 21% (normoxic) oxygen levels using MCF-7 and HeLa cells. Our results showed that NPs of size 50 nm had the highest uptake following prolonged exposure to hypoxia. There was no significant toxicity introduced by NPs under hypoxic conditions. These findings will play a vital role in the optimization of GNP-based therapeutics in cancer treatment.

Cellular uptake of colloidal gold nanoparticles in a tumor-like environment (hypoxic). A. Enhanced uptake of 15, 50, and 70 nm GNPs under hypoxic conditions. GNPs of size 50 nm showed the highest uptake under both normoxic and hypoxic conditions. B–C. Hyperspectral images of cells incubated with GNPs under normoxic and hypoxic conditions, respectively.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Interface Science Communications - Volume 1, August 2014, Pages 57–61
نویسندگان
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