کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5915656 1163319 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewSpecializations in a successful parasite: What makes the bloodstream-form African trypanosome so deadly?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
ReviewSpecializations in a successful parasite: What makes the bloodstream-form African trypanosome so deadly?
چکیده انگلیسی

Most trypanosomatid parasites have both arthropod and mammalian or plant hosts, and the ability to survive and complete a developmental program in each of these very different environments is essential for life cycle progression and hence being a successful pathogen. For African trypanosomes, where the mammalian stage is exclusively extracellular, this presents specific challenges and requires evasion of both the acquired and innate immune systems, together with adaptation to a specific nutritional environment and resistance to mechanical and biochemical stresses. Here we consider the basis for these adaptations, the specific features of the mammalian infective trypanosome that are required to meet these challenges, and how these processes both inform on basic parasite biology and present potential therapeutic targets.

127Highlights► African trypanosomes overcomes many challenges in the mammalian host. ► Firstly, a specialized morphology and biochemical processes adapting to the mammalian bloodstream common to all trypanosomatids. ► Secondly, antigenic variation and accessory immune evasion systems, common to all African trypanosomes. ► Thirdly, specific mechanisms to avoid innate immune defense mechanisms of humans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Biochemical Parasitology - Volume 179, Issue 2, October 2011, Pages 51-58
نویسندگان
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