کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5916342 | 1570718 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer
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کلمات کلیدی
MDAPD1IL-24IFN-γPBMCsCTLA4immunotherapy - ایمونوتراپیInterferon-α - اینترفرون-αInterleukin-24 - اینترلوکین -24Tumor infiltrating lymphocytes - تومور لنفوسیت ها نفوذ می کندTILS - جریان بداخلperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیT cells - سلول های تیCytokine - سیتوکینprogrammed cell death 1 - مرگ سلولی برنامه ریزی شده 1Tumor microenvironment - میکرو محیط زیست تومورcytotoxic T-lymphocyte-associated protein 4 - پروتئین مرتبط با لنفوسیت T تری سیتوتوکسی 4
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
Interleukin-24 (IL-24) is a novel tumor suppressor and can mediate the induction of Th1-type cytokines from peripheral blood mononuclear cells. The individual properties of IL-24 have been previously examined; however, its in vivo immunological consequences and antitumor properties have not been previously evaluated with respect to colon cancer, the most commonly diagnosed cancer in China. Thus, we evaluated whether IL-24 could inhibit the progression of colon cancer in murine models with intact immune competence and explored the mechanisms underlying the immunological effects of IL-24 on colon cancer progression in vivo. In these murine models, we found that IL-24 promoted CD4+ T cells and CD8+ T cells to secrete interferon gamma and enhanced the cytotoxicity of CD8+ T cells in vivo. More importantly, we demonstrated that IL-24 transformed the tumor microenvironment and enhanced antitumor effects in favor of tumor eradication. Additionally, IL-24 expression correlated inversely with the clinical stage of human colorectal cancer. Thus, our study establishes a role of IL-24 in promoting antitumor immune responses and supports the development of a novel cytokine immunotherapy against colon cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 75, July 2016, Pages 11-20
Journal: Molecular Immunology - Volume 75, July 2016, Pages 11-20
نویسندگان
Yun-Feng Ma, Yi Ren, Cai-Jun Wu, Xiao-Hui Zhao, Hua Xu, Da-Zhou Wu, Jiru Xu, Xiao-Lian Zhang, Yanhong Ji,