کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5916586 1163752 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Renal expression of Toll-like receptor 2 and 4: Dynamics in human allograft injury and comparison to rodents
ترجمه فارسی عنوان
بیان کلیه گیرنده های 2 و 4 مانند: دینامیکی در آسیب های آلوگرافی انسان و مقایسه آن با جوندگان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
چکیده انگلیسی
Human kidney biopsies obtained from living kidney donors and patients with acute tubular necrosis, acute cellular and vascular rejection and interstitial fibrosis/tubular atrophy (IF/TA) were used. Translating results from animal studies to the clinical situation is highly important considering the upcoming clinical studies with TLR inhibitors in human renal transplantation. Hence, the TLR2 and TLR4 expression in healthy mouse and rat kidneys was analyzed and compared with human kidneys. In healthy human kidneys, TLR2 is expressed on the endothelium and Bowman's capsule, while TLR4 is expressed on the endothelium only. No tubular staining was found for both receptors in human kidneys. In contrast to human biopsies, TLR2 and TLR4 expression in rodents was observed on tubular epithelial cells. In all acute rejection human biopsies, increased infiltration of TLR4+ leukocytes was observed. In conclusion, a discrepancy exists between human and rodent renal TLR expression, which suggests careful attention when translating results from rodent studies to the human situation. Additionally, this study revealed human TLR2 and TLR4 expression dynamics in human biopsies pre- and post-transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 64, Issue 1, March 2015, Pages 82-89
نویسندگان
, , , , , , , ,