Simultaneous immunisation with a Wilms' Tumour 1 epitope and its ubiquitin fusions results in enhanced cell mediated immunity and tumour rejection in C57BL/6 mice

► Targeting a protein to UFD or N-end proteasome pathway lead to in its degradation. ► Targeting antigen to UFD resulted in better cytotoxic response than N-end pathway. ► Targeting antigen to UFD or N-end proteasome pathway caused tumour regression. ► Co-immunization with ubiquitin-TAA and TAA resulted in tumour protection. ► Co-immunization with ubiquitin-TAA and TAA resulted in TH1 immunity.