Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation

► Here we investigated the expression of nuclear receptors (NRs) in mast cells. ► We show that Gram-negative bacteria cause upregulated NR4a expression in mast cells. ► NR4a expression is also induced by LPS and by IgE receptor cross-linking. ► NR4a expression is strongly dependent on Gö6976-sensitive kinases. ► NR4a expression is dependent on the nuclear factor of activated T-cells (NFAT) pathway.