Age, sex, and handedness differentially contribute to neurospatial function on the Memory Island and Novel-Image Novel-Location tests

► Males show more efficient navigation on MI but females show better object recognition on NINL. ► Adolescents and younger-adults outperform children and older ages on MI. ► Peformance on the NINL test is largely age-independent. ► Left-handers show better performance than right-handers on the MI and NINL tests. ► Sex, age, and, possibly, handedness contribute to neurospatial behavior.