کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5932675 | 1573379 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases
ترجمه فارسی عنوان
عملکرد پاتوفیزیولوژیک پپتید مرتبط با ژن کلاسیتونیون اندوژن در بیماری های عروقی چشم
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Calcitonin gene-related peptide (CGRP; official name CALCA) has a variety of functions and exhibits both angiogenic and anti-inflammatory properties. We previously reported the angiogenic effects of the CGRP family peptide adrenomedullin in oxygen-induced retinopathy; however, the effects of CGRP on ocular angiogenesis remain unknown. Herein, we used CGRP knockout (CGRPâ/â) mice to investigate the roles of CGRP in ocular vascular disease. Observation of pathological retinal angiogenesis in the oxygen-induced retinopathy model revealed no difference between CGRPâ/â and wild-type mice. However, much higher levels of the CGRP receptor were present in the choroid than the retina. Laser-induced choroidal neovascularization (CNV), a model of exudative age-related macular degeneration, revealed more severe CNV lesions in CGRPâ/â than wild-type mice, and fluorescein angiography showed greater leakage from CNV in CGRPâ/â. In addition, macrophage infiltration and tumor necrosis factor (TNF)-α production were enhanced within the CNV lesions in CGRPâ/â mice, and the TNF-α, in turn, suppressed the barrier formation of retinal pigment epithelial cells. In vivo, CGRP administration suppressed CNV formation, and CGRP also dose dependently suppressed TNF-α production by isolated macrophages. From these data, we conclude that CGRP suppresses the development of leaky CNV through negative regulation of inflammation. CGRP may thus be a promising therapeutic agent for the treatment of ocular vascular diseases associated with inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Pathology - Volume 185, Issue 6, June 2015, Pages 1783-1794
Journal: The American Journal of Pathology - Volume 185, Issue 6, June 2015, Pages 1783-1794
نویسندگان
Yuichi Toriyama, Yasuhiro Iesato, Akira Imai, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Akihiro Yamauchi, Kyoko Igarashi, Megumu Tanaka, Tian Liu, Xian Xian, Liuyu Zhai, Shinji Owa, Toshinori Murata, Takayuki Shindo,