کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5935814 1573401 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epithelial Membrane Protein 2 Is a Prognostic Indictor for Patients with Urothelial Carcinoma of the Upper Urinary Tract
ترجمه فارسی عنوان
پروتئین غشایی اپیتلیال 2 یک شاخص پیش آگهی برای بیماران مبتلا به سرطان پروستات در دستگاه ادراری فوقانی است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Upper urinary tract urothelial carcinoma is a relatively uncommon disease and is diagnosed more frequently at advanced stages. The prognosis of these patients mainly has been related to tumor stage and grade. As a result, the definition of prognostic indicators enabling precise patient selection is mandatory for neoadjuvant or adjuvant therapies. The epithelial membrane protein (EMP2) was identified as one of the up-regulated genes by isoflavones. EMP2 overexpression suppressed foci formation, anchorage-independent growth in vitro, and tumorigenicity in severe combined immunodeficiency mice (all P < 0.05). In addition, a cross-talk between EMP2 and integrins αV and β3 was shown in the regulation of cell adhesion and migration. Higher EMP2 expression was associated with a better progression-free survival (P = 0.008) and cancer-related death (P < 0.001). EMP2 was identified as a tumor-suppressor gene in urinary tract urothelial carcinoma and may be an innovative co-targeting candidate for designing integrin-based cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Pathology - Volume 183, Issue 3, September 2013, Pages 709-719
نویسندگان
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