کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5944247 1172342 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between serum gamma-glutamyltransferase and the progression of coronary artery calcification
ترجمه فارسی عنوان
ارتباط بین گاما گلوتامیل ترانسفراز سرم و پیشرفت کلسیفیکاسیون عروق کرونر
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- Serum GGT activity has been reported to be independently associated with CAC.
- Progression of CAC is a better mirror of activity of atherosclerosis progression.
- Serum GGT levels are independently associated with the progression of CAC.
- Our results support the role of serum GGT as a predictive of future CHD prognosis.

BackgroundElevated serum gamma-glutamyltransferase (GGT) has been demonstrated to be associated with coronary artery calcification (CAC). CAC progression is an important marker of atherosclerosis and correlates with future cardiovascular risk. However, there is a lack of research that directly examines the association between serum GGT and CAC progression. The aim of this study was to elucidate the association between serum GGT activity and CAC progression.MethodsWe enrolled 1246 asymptomatic participants who underwent repeated CAC score measurement during routine health examinations. To eliminate the dependence of the inter scan variability on the baseline CAC scores, square root-transformed CAC scores were used to analyze CAC progression. In addition, the annualized rate of change in CAC scores was computed.ResultsSerum GGT activities were significantly higher in “progressors” than “nonprogressors”. The prevalence of progression increased with the GGT tertile (11.9%, 20.1% and 27.9% in the 1st, 2nd, and 3rd GGT tertiles, respectively; p < 0.001). In the multivariate logistic regression analysis, the odds ratio (95% confidence interval) for CAC score progression was 1.85 (1.14-3.00) in the highest GGT tertile group. By multivariate linear regression analysis, baseline serum GGT activity demonstrated a positive association with the annualized change in CAC score (β = 0.002; p = 0.006) after adjusting for cardiovascular risk factors.ConclusionElevated serum GGT levels are independently associated with CAC progression. Serum GGT levels may be a potential biomarker of future coronary atherosclerosis and prognosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 243, Issue 1, November 2015, Pages 300-306
نویسندگان
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