کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5945849 1172355 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: Exploring common genetic and environmental factors
ترجمه فارسی عنوان
ارتباط بین اسیدهای چرب سرم و پروتئین زیر رده لیپوپروتئین در سالمندان جوان: بررسی عوامل ژنتیکی و محیطی مشترک
کلمات کلیدی
اسیدهای چرب سرم مشخصات لیپوپروتئین، دوقلوها، پلیوتروپین ژنتیکی، فاکتورهای محیطی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- Serum n-6 PUFAs are strongly and inversely correlated with TG and VLDL particles.
- Serum MUFAs are strongly and positively correlated with TG and VLDL particles.
- Shared genetic factors are important in explaining these associations.
- This has implications for interventions designed to lower atherogenic lipids.
- Correlations of n-3 PUFAs with TG and VLDL particles are weaker.

ObjectiveLittle is known about the associations of serum fatty acids with lipoprotein profile and the underlying genetic and environmental etiology of these relationships. We aimed to analyze the phenotypic association of serum n-6 and n-3 polyunsaturated (PUFAs), monounsaturated (MUFAs) and saturated (SFAs) fatty acids (relative proportion to total fatty acids) with lipids and lipoproteins, and to quantify common genetic and environmental factors determining their covariation.MethodsTwo cohorts of healthy Finnish twins were assessed in young adulthood. Data were available for 1269 individual twins including 561 complete pairs. Serum metabolites were measured by nuclear magnetic resonance spectroscopy. Bivariate quantitative genetic models were used to decompose the phenotypic covariance between the pairs of traits into genetic and environmental components.ResultsAmong the strongest correlations observed, serum total n-6 PUFAs and linoleic acid were inversely (max. r = −0.65) and MUFAs positively (max. r = 0.63) correlated with triglycerides and very low-density lipoprotein (VLDL) particle concentration, particularly with large VLDL (for n-6 PUFAs) and medium VLDL (for MUFAs). Genetic factors significantly contributed to their covariance with bivariate heritability estimates ranging from 44% to 56% for n-6 PUFAs and 58% to 66% for MUFAs. Genetic correlations with lipid traits were moderate to high (max. rA = −0.59 and 0.70 for n-6 PUFAs and MUFAs, respectively). Statistically significant, but substantially weaker phenotypic correlations of total n-3 PUFAs, docosahexaenoic acid (DHA) and SFAs with lipoprotein profile were not decomposed into their genetic and environmental components.ConclusionShared genetic factors are important in explaining why higher concentrations of serum n-6 PUFAs and lower concentrations of serum MUFAs strongly associate with lower triglyceride and VLDL particle concentrations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 233, Issue 2, April 2014, Pages 394-402
نویسندگان
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