کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5946354 1172358 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic and environmental effects on carotid flow velocities: An international twin study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Genetic and environmental effects on carotid flow velocities: An international twin study
چکیده انگلیسی


- No study has been performed among adult twins to investigate the role of genetic factors in carotid flow velocities.
- Cardiovascular patient (hypertensive, diabetics) undergoes several imaging studies to assess the total atherosclerotic burden within various vascular districts. Carotid arteries Doppler ultrasound is the employed and widespread imaging modalities.
- Ischemic stroke has a major impact on public health as leading cause of long-term disability and third cause of death.
- Our study showed for the first time in adult twins that ICA PSV is moderately heritable, environmental effects account for a moderate to major portion of the variance of the ICA EDV and CCA CFV traits.

IntroductionAltered carotid blood flow velocities (CFV) have a complex background but the underlying genetic contribution is still unclear. We sought to evaluate the influence of genetics, shared and unshared environmental components on individual differences of CFV.Methods193 healthy twin pairs, 126 monozygotic (MZ) and 67 dizygotic (DZ) (mean age 53 ± 14 years) recruited in Italy, in the United States and in Hungary underwent bilateral color-coded Doppler flow assessment of the common carotid artery (CCA) and of the internal carotid artery (ICA) in order to assess the peak systolic (PSV) and end diastolic (EDV) velocities. Means of bilateral CFV values were used in the analysis.ResultsAge- and country-adjusted intra-class correlations were higher in monozygotic than in dizygotic pairs for mean PSV of the ICA indicating a heritability of 63%. Unique environmental factors contributed to 37% of ICA PSV. With regards to the mean PSV and EDV of the CCA, and EDV of the ICA, heritability analysis indicated no discernible role for genetic components, while the contributions of shared and unshared environmental factors ranged between 56% and 63%, and between 37% and 44% adjusted for age and country, respectively. Mean ICA/CCA ratio was driven by unique environmental factors (82%) with modest heritability (18%).ConclusionsOur study showed that the heritability of ICA PSV and ICA/CCA ratio is moderate, while the findings do not support heritability of other investigated CFV values. Environmental effects account for a moderate to major portion of the variance. These findings support the value of early ultrasound screening as well as the prevention of modifiable environmental factors in case of altered carotid flow velocities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 231, Issue 2, December 2013, Pages 205-210
نویسندگان
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