کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5946369 1172358 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: Cardiovascular Health Study
ترجمه فارسی عنوان
تاثیر بیومارکرهای التهابی بر ارتباط چربی لیپوپروتئین با کلسترول با بیماری قلبی عروقی: مطالعه سلامت قلب و عروق
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- We examined whether inflammation impacts on the relation of HDL-C with CHD events.
- We investigated inflammatory factors C-reactive protein, interleukin-6, and LpPla2.
- Increased inflammation attenuated the protective relation of high HDL-C with CHD.
- At all levels of HDL-C, increased inflammation was associated with higher CHD risk.

BackgroundInflammatory factors and low HDL-C relate to CHD risk, but whether inflammation attenuates any protective association of high HDL-C is unknown.ObjectiveInvestigate inflammatory markers' individual and collective impact on the association of HDL-C with incident coronary heart disease (CHD).MethodsIn 3888 older adults without known cardiovascular disease (CVD), we examined if the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and lipoprotein-associated phospholipase A2 (Lp-PLA2) modify the relation of HDL-C with CHD. HDL-C, CRP, IL-6, and Lp-PLA2 values were grouped as using gender-specific tertiles. Also, an inflammation index of z-score sums for CRP, IL-6, and Lp-PLA2 was categorized into tertiles. We calculated CHD incidence for each HDL-C/inflammation group and performed Cox regression, adjusted for standard CVD risk factors and triglycerides to examine the relationship of combined HDL-C-inflammation groups with incident events.ResultsCHD incidence (per 1000 person years) was higher for higher levels of CRP, IL-6, and the index, and lower for higher levels of HDL-C. Compared to high HDL-C/low-inflammation categories (referent), adjusted HRs for incident CHD were increased for those with high HDL-C and high CRP (HR = 1.50, p < 0.01) or highest IL-6 tertile (HR = 1.40, p < 0.05), but not with highest Lp-PLA2 tertile. Higher CHD incidence was similarly seen for those with intermediate or low HDL-C accompanied by high CRP, high IL-6, or a high inflammatory index.ConclusionThe protective relation of high HDL-C for incident CHD appears to be attenuated by greater inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 231, Issue 2, December 2013, Pages 246-251
نویسندگان
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