Effects of atorvastatin on human C-reactive protein metabolism

► Statins are known to reduce plasma C-reactive protein (CRP) concentrations. ► We aim to define the effects of atorvastatin 80 mg/day vs placebo on CRP kinetics. ► Atorvastatin lower plasma CRP levels by substantially increasing CRP catabolism. ► There was no significant effect of atorvastatin on CRP production rate.