Platelet-derived microparticles augment the adhesion and neovascularization capacities of circulating angiogenic cells obtained from atherosclerotic patients

► Circulating angiogenic cells (CACs) have neovascularization capacities. ► Platelet-derived microparticles (PMPs) augmented adhesion capacity of CACs. ► PMP-pretreated CACs injection augmented neovascularization of mice ischemic limbs. ► PMP-released RANTES may play a role in the augmented effect for CACs. ► PMP-pretreated CACs injection may be a new strategy of therapeutic angiogenesis.