کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5947877 | 1172374 | 2013 | 5 صفحه PDF | دانلود رایگان |
- We examined women with previous normotensive or hypertensive pregnancies.
- The ankle-brachial index was measured decades after pregnancy.
- Peripheral arterial disease (PAD) was defined as an ankle-brachial index â¤0.9.
- Women with a previous hypertensive pregnancy were more likely to have PAD.
BackgroundAn ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value â¤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI â¤0.9 decades after pregnancy.Methods and resultsABI was measured in nulliparous women (n = 144), and women with a history of normotensive (n = 1272) or hypertensive (n = 281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean) ± 10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p = 0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p = 0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p = 0.87).ConclusionsHypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.
Journal: Atherosclerosis - Volume 229, Issue 1, July 2013, Pages 212-216