کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5947959 1172375 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preinfarction angina does not affect infarct size in STEMI patients undergoing primary angioplasty
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Preinfarction angina does not affect infarct size in STEMI patients undergoing primary angioplasty
چکیده انگلیسی

BackgroundSeveral clinical studies have demonstrated that anginal attacks shortly before the onset of STEMI limit infarct size and improve short- and long-term outcomes. However, the clinical significance of preinfarction angina in STEMI patients treated by primary PCI is still controversial. Therefore, the aim of the current study was to evaluate the impact of preinfarction angina on scintigraphic infarct size in STEMI patients undergoing primary PCI.MethodsOur population is represented by 430 STEMI patients undergoing primary PCI. Infarct size was evaluated at 30 days by technetium-99m-sestamibi.ResultsPreinfarction angina was associated with more advanced age, a larger prevalence of family history for CAD, smoking, and longer ischemia time. No difference was observed in other clinical or angiographic characteristics. Preinfarction angina did not affect either the rate of postprocedural TIMI 3 flow or infarct size (19 ± 15.5 vs 16 ± 13.9, p = 0.18). Similar results were observed in subanalyses according to infarct location (anterior STEMI: 22.7 ± 14.8 vs 19.2 ± 16.1, p = 0.36; non-anterior STEMI: 16.1 ± 15.7 vs 13.8 ± 11.6, p = 0.36), gender (female gender: 15.6 ± 14.5 vs 11.5 ± 13.2, p = 0.30; male gender 20.4 ± 16 vs 17.2 ± 13.8, p = 0.3) or ischemia time (≤ or > 4 h) (17.6 ± 15.6 vs 15.8 ± 14.1, p = 0.52; 21.6 ± 15.5 vs 16.7 ± 13.3, p = 0.18). The absence of any impact of preinfarction angina on infarct size was confirmed after correction for baseline characteristics, such as age, smoking, family history for CAD and ischemia time (OR [95% CI] = 1.26 [0.66-2.41], p = 0.48).ConclusionsThis study shows that among STEMI patients undergoing primary PCI preinfarction angina does not affect infarct size.

► Anginal attacks shortly before the onset of STEMI seems to limit infarct size. ► However, its role in STEMI treated by primary PCI is still controversial. ► In our study preinfarction angina did not affect infarct size after primary PCI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 226, Issue 1, January 2013, Pages 153-156
نویسندگان
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