Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid

► Studying the role of PON1 in blood pressure (BP) regulation, using paraoxonase1 knockout (PON1KO) mice. ► Reduced BP observed in PON1KO is RAAS- and NO-independent. ► A direct, causal relation between PON1 and BP was observed. ► BP is inversely related to 5,6-EET which is regulated by PON1. ► Endothelial-derived hyperpolarization-like response is probably involved in the reduced BP in PON1KO mice.